The strike, which was the third since Monday night, took place in New Adda area, 35 kilometres (21 miles) west of Miranshah, the main town in North Waziristan tribal district.
US drones fired four missiles targeting a vehicle and an adjacent compound, killing eight people. Two missiles each were fired on the vehicle and the compound.
The death toll in three US drone strikes both in North and South Waziristan has reached 31.
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